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Insulin Placement in the Portal Vein

by Edward D. Murphy, MD

We will place insulin in the portal vein of diabetics.

Evanston, IL Diabetes

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All Team Company Patients Physicians Mission Supporters

About this project

The problem we solve:
Pancreatic insulin production is followed by insulin secretion into the portal venous system. Diabetes results from a relative or absolute insufficiency of insulin production and secretion into this system. Insulin treated diabetic patients receive their external insulin in a peripheral site, not into the portal system. This results in peripheral hyperinsulinemia, which is associated with increased arterial vascular disease.
About our solution:
With the use of the subcutaneous "button" and a catheter to the portal vein, We shall place insulin into the portal system as has been done in animals, decreasing inappropriate peripheral hyperinsulinemia and its sequellae, as we more closely imitate normal insulin secretion and physiology.
Progress to date: We have placed insulin in the portal vein of dogs with control of diabetes and lower peripheral insulin levels than in subcutaneously administered insulin receiving animals.

About Our Team

Dr. Edward D. Murphy, MD
Endocrinology, Practicing Physician
Medical school: University of Chicago
Bio: Retired Physician, medical educator, clinician and researcher.
Hospital Affiliation: NorthShore University HealthSystem
Title: Senior Clinician

About Our Company

NorthShore University HealthSystem
Location: Evanston, Illinois
Product stage: idea
Sales: Working on it
Employees: 1-2

How We Help Patients

We will control diabetes without creating peripheral hyperinsulinemia and thus will decrease vascular disease in patients with diabetes by placing insulin into the portal system rather than peripherally.

How We Help Physicians

Insulin will be administered in a more physiologic manner with better glucose control and less peripheral hyperinsulinemia.

Challenge Mission

Mission: People with diabetes will avoid marked peripheral hyperinsulinemia under the guidance of physicians.
Use of funds: Will aid in further publication of data.
Intellectual Property Status: not applicable
FDA Status: not applicable
Personal Message: We wish to emphasize placement of insulin at the proper physiologic site in patients with diabetes.

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    05/21/2016 Molly Demarco - Pharmaceutical Staff

    Interested in trying the project.

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    05/21/2016 Molly Demarco - Pharmaceutical Staff

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Edward D. Murphy, MD
Private
Senior Clinician
University of Chicago

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